Synonyms: 6-(1H-Imidazol-1-yl)-N-[2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3-pyridazinecarboxamide; N-(2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-6-(1H-imidazol-1-yl)pyridazine-3-carboxamide; SR 301; SR301
Molecular Formula: C17H11F6N5O2
Molecular Weight: 431.29
Linear Structural Formula: C17H11F6N5O2
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: SR-301 is an orally bioavailable analog of the selective STING agonist SR-717. SR-301 shows higher potency than SR-717 by THP1-based ISRE reporter assay (EC50 = 0.6 vs. 2.1 muM, respectively) and shows good antitumor efficacy when administered orally in a murine B16.F10 melanoma tumor model in vivo (15 mg/kg/day p.o.).