Sodium dodecyl sulfate (SDS) is an anionic detergent suitable to denature proteins. It has a long-chain aliphatic group with negatively charged sulfate attached. This makes SDS an amphipathic detergent.
Synonyms: Dodecyl sodium sulfate; Dodecyl sulfate sodium salt; Lauryl sulfate sodium salt; SDS; Sodium lauryl sulfate
Molecular Formula: C12H25NaO4S
Molecular Weight: 288.38
Linear Structural Formula: CH3(CH2)11OSO3Na
MDL Number: MFCD00036175
Purity: >=98.5% (GC)
Melting Point: 204-207 C (lit.)
Application: Used to solubilize and denature proteins for denaturing-PAGE. Most proteins bind SDS in a ratio of 1.4 g SDS per gram of protein. The charges intrinsic to the protein become insignificant compared to the overall negative charge provided by the bound SDS. The charge to mass ratio is essentially the same for each protein and will migrate in the gel based only on their size.
RTECS: WT1050000
RIDADR: UN1325 - class 4.1 - PG 3 - Flammable solids, organic, n.o.s., HI: all
WGK Germany: 2
Flash Point(F): 338 F
Flash Point(C): 170 C
R Codes: 11-21/22-37/38-41
S Codes: 26-36/37-39
IOD Codes: F,Xn
Symbol: GHS02, GHS05, GHS07
Signal Word: Danger
Hazard Statements: H228-H302 + H332-H315-H318-H335-H412
Precautionary statements: P210-P261-P280-P301 + P312 + P330-P305 + P351 + P338 + P310-P370 + P378