Synonyms: 4-(3'-(3",5"-Dimethylphenyl)ureido)phenyl sulfamate; 4-[(3,5-Dimethylphenyl)ureido]phenyl sulfamate; 4-[[[(3,5-Dimethylphenyl)amino]carbonyl]amino]phenyl sulfamic acid ester
Molecular Formula: C15H17N3O4S
Molecular Weight: 335.38
Linear Structural Formula: C15H17N3O4S
MDL Number: MFCD30182321
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: S4 is a potent and selective inhibitor against sulfamate carbonic anhydrase (CA) subtypes CAIX & CAXII (Ki = 2, 7, 546, 5600 nM against human CA XII, IX, II, and I, respectively). S4 selectively inhibits migration upon anoxia/hypoxia-induced CAIX expression in cancer cultures (% inhibition/conc./cell line = 54%/100 muM/WRO, 65%/33 muM/MDA-MB-231), while exhibiting no inhibitory effects under normoxia or among non-CAIX-expressing cells (HCT116 & RT112). Daily intraperitoneal injection (10 mg/kg) is reported to reduce the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors in vivo.