Synonyms: (3E,5E)-3,5-Bis[(4-Nitrophenyl)methylene]-4-piperidinone
Molecular Formula: C19H15N3O5
Molecular Weight: 365.34
Linear Structural Formula: C19H15N3O5
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. RA-9 directly inhibits activity of following DUB UCH-L1, UCH-L3, USP2, USP5 and USP8 deubiquitinating enzymes, which results in rapid accumulation of poly-ubiquitinated proteins leading to cell cycle checkpoint arrest and tumor cell apoptosis.