Synonyms: 1,3-Dimethyl-2-(2-oxopropylthio)-1H-imidazol-3-ium chloride; 1,3-Dimethyl-2-[(2-oxopropyl)thio]imidazolium chloride; NTU283; Rob283
Molecular Formula: C8H13N2OS · Cl
Molecular Weight: 220.72
Linear Structural Formula: C8H13N2OS · Cl
MDL Number: MFCD00898949
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: R283 (NTU283; Rob283) is a cell-permeable 2-[(2-oxopropyl)thio] imidazolium derivative that acts as an irreversible inhibitor against factor XIIIa (FXIIIa) and transglutaminase 2 (TG2, TGase II) by targeting FXIIIa and TG2 active site cysteine (Cys) for acetonylation in a selective manner with little glutathione (GSH) inhibitory potency (app 2nd order rate const = 23000/M/s, 19000/M/s, 0.12/M/s, respectively). A useful tool for investigating TG2-mediated cellular functions (typical conc. range: 25-500 muM).