Synonyms: (R)-N-(isoquinolin-1-yl)-3-(4-methoxyphenyl)-N-(piperidin-3-yl)propanamide hydrochloride
Molecular Formula: C24H27N3O2 · xHCl
Linear Structural Formula: C24H27N3O2 · xHCl
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: R-IMPP is a potent and selective inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) secretion that stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin. R-IMPP binds selectively to human ribosomes and causes transcript-dependent inhibition of PCSK9 translation.