Purity: >=85% (SDS-PAGE)
Storage: -20C
UNSPSC Code: 12352202
General description: p53 is regulated by MDM2, which acts as a negative regulator of p53 transcription by promoting its degradation by functioning as an E3 ubiquitin ligase which recognizes the N′ terminal transactivation domain.
Application: Useful for the study of postranslational modification of p53, or protein-protein interaction studies.
Biochem/physiol Actions: p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.
Physical properties: GST-tagged, full-length human p53
RIDADR: NONH for all modes of transport
WGK Germany: 1