Synonyms: 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide; PFT-α
CAS Number: 63208-82-2
Formula: C16H18N2OS · HBr
Formula Weight: 367.3
Linear Formula: C16H18N2OS·HBr
MDL No.: MFCD00417851
Purity: >=95% (HPLC)
Melting Point: 192.1-192.5 C (lit.)
Storage: -20C
UNSPSC Code: 12352200
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Biochem/physiol Actions: Pifithrin-α is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. Pifithrin-α enhances cell survival after genotoxic stress such as UV irradiation and treatment with cytotoxic compounds including doxorubicin, etopoxide, paclitaxel, and cytosine-β-D-arabinofuranoside. Pifithrin-α protects mice from lethal whole body γ-irradiation without an increase in cancer incidence. The protective effect is not seen in p53-null mice or cells expressing a dominant negative mutant of the p53 gene. Protection is conferred by the transient expression of p53 in p53-deficient cell lines.
RIDADR: NONH for all modes of transport
WGK Germany: 3