Prothionamide is an analogue of ethionamide, and is better tolerated and less toxic than ethionamide. It contains a propyl group instead of an ethyl group at the a position.
Synonyms: Prothionamide; 2-propyl-4-pyridinecarbothioamide; 2-propylisonicotinylthioamide; 2-propylthioisonicotinamide; 2-Propyl-4-pyridinecarbothioamide; 2-Propylisonicotinylthioamide
Molecular Formula: C9H12N2S
Molecular Weight: 180.27
Linear Structural Formula: C9H12N2S
MDL Number: MFCD00464119
Purity: >=99% (HPLC)
Storage: -20C
Biochem Physiol Actions: Prothionamide is the second line of drug used in leprosy and in tuberculosis. It is highly effective against Mycobacterium tuberculosis. In patients with multidrug-resistant tuberculosis (MDR-TB), prothionamide causes the development of hepatitis. In rare cases, it causes drug reaction with eosinophilia and systemic symptoms (DRESS) in patients with MDR-TB. DRESS is characterized by fever, hematologic abnormalities, skin eruption, and internal organ disruption.
Other Notes: Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids