Synonyms: 9-Ethyl-N-methyl-9H-Carbazole-3-methanamine hydrochloride; PK-083 hydrochloride; PK083 hydrochloride; PhiKan-083 hydrochloride
Molecular Formula: C16H18N2 · HCl
Molecular Weight: 274.79
Linear Structural Formula: C16H18N2 · HCl
MDL Number: MFCD07168924
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: PhiKan083 is a small molecule that binds within a cavity on the surface of Y220C-mutated p53. This mutation, which is not involved in DNA interaction, causes a destabilization of the protein. PhiKan083 binding acts to stabilize the mutant p53 and slow the rate of denaturation.