Synonyms: (5Z)-2-Amino-5-[(4-aminophenyl)methylene]-4(5H)-thiazolone; 5-(4-Aminobenzylidene)-2-iminothiazolidin-4-one
Molecular Formula: C10H9N3OS
Molecular Weight: 219.26
Linear Structural Formula: C10H9N3OS
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: PFM39 is a potent cell-permeable Mirin analog that selectively inhibits MRE11 exo-, but not endo-, nuclease activity. PFM39 targets MRE11 in a fashion similar to Mirin, but distinct from that of PFM01 to allow a blockage of dsDNA phosphate backbone rotation and selective inhibition against MRE11 exo-, but not endo-, nuclease activity. FM39 potently impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR).