Synonyms: (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-(2-propyn-1-yloxy)-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(prop-2-yn-1-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide; Probe 8
Molecular Formula: C23H21ClFN5O2
Molecular Weight: 453.9
Linear Structural Formula: C23H21ClFN5O2
MDL Number: MFCD28386021
Purity: >=95% (HPLC)
Storage: room temp
Biochem Physiol Actions: PF-06672131 is a selective EGFR kinase inhibitor thought to covalently react with active-site cysteine residues in the ATP binding pocket. PF-06672131 has been used as a probe for proteomic analysis to identify off-target binding substrates. The dimethylaminomethyl (DMAM) group appears to increase compound stability in cancer cells with a resultant increase in protein reactivity from selective EGFR binding to widespread proteome-wide reactivity after treatment.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.