Synonyms: 6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide; PF 6281355; PF-1355
Molecular Formula: C14H15N3O4S
Molecular Weight: 321.35
Linear Structural Formula: C14H15N3O4S
Purity: >=98% (HPLC)
Storage: room temp
Biochem Physiol Actions: PF-06281355 (PF-1355) is an orally available, selective and potent mechanism based inhibitor of the myeloperoxidase (MPO) that reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevated circulating cytokines. PF-06281355 suppresses albuminuria and chronic renal dysfunction in model of anti-Glomerular Basement Membrane (GBM) disease.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.