Synonym: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
CAS Number: 391210-10-9
Empirical Formula (Hill Notation): C16H14F3IN2O4
Molecular Weight: 482.19
MDL Number: MFCD08435926
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Biochem/physiol Actions
PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.
Assay: =98% (HPLC)
Form: powder
Optical Activity: [a]/D -1.8 to -3.0°, c = 1 mg/mL in methanol
Color: white to off-white
Solubility: DMSO: =20 mg/mL
Storage Temp.: 2-8°C