Synonyms: 9,10-Dihydro-8-hydroxy-3-methoxy-1,7-dimethyl-9,10-dioxo-2-anthracenecarboxylic acid ethyl ester; G01
Molecular Formula: C20H18O6
Molecular Weight: 354.35
Linear Structural Formula: C20H18O6
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Oxanthroquinone G01 is a potent inhibitor of KRAS and NRAS plasma membrane localization that potently inhibits proliferation of KRAS transformed cancer cells. Oxanthroquinone G01 also inhibits recycling of epidermal growth factor receptor and transferrin receptor, but has no influence on cholera toxin internalization. It also increases cellular levels of sphingomyelin and and ceramide.