Synonyms: (alphaR)-alpha-[[(1,2-Dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-benzeneacetamide; OSMI 1
Molecular Formula: C28H25N3O6S2
Molecular Weight: 563.64
Linear Structural Formula: C28H25N3O6S2
Purity: >=98% (HPLC)
Storage: 2-8C
Application: OSMI-1 (OGT with a small molecule inhibitor) has been used in proximal ligation assay, Sox2 (SRY (sex determining region Y)-Box 2 ) dual luciferase reporter assay, Sox2 ELISA (enzyme linked immunosorbent assay) and other in vivo approaches, to study the O-Linked ß-N-acetylglucosamine (O-GlcNAc) mediated regulation of self-renewal genes in cancer. It has also been used to study the Hippo pathway regulation mediated by O-GlcNAc transferase.
Biochem Physiol Actions: OSMI-1 is a cell permeable inhibitor of OGT (O-GlcNAc transferase).