This ELISA antibody pair detects mouse and human PAI-1.
Storage: -20C
Application: For research use only. Not for use in diagnostic procedures.Please refer to the attached Protocolfor details.
Biochem Physiol Actions: PAI-1 (plasminogen activator inhibitor) produced by platelets takes part in stabilizing blood clotting mechanism. PAI-1 prevents plasminogen activation during fibrinolysis. This might lead to the risk of cardiovascular disease. Elevated levels of PAI-1 has been observed in type 2 diabetes mellitus and serves the reason for reduced insulin sensitivity. PAI-1 stimulates the process of cellular senescence. PAI-1 regulation occurs through p53 dependent TGF-ß (transforming growth factor-ß) signalling. Studies also also predict that stress and depression might influence PAI-1 expression.
Other Notes: A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.