Synonyms: Anti-A-Kinase Anchor Protein 12; Anti-AKAP12
MDL No.: MFCD08705585
Storage: -20C
UNSPSC Code: 12352203
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General description: Gravin (or AKAP12) is a scaffolding kinase that functions as a tumor suppressor. This kinase interacts with PKC, PKA and other cell cycle signaling proteins to modulate cell division, growth, differentiation and inflammatory responses. The expression of gravin isoforms (α, β, and γ) is regulated by tissue-specific promoters. Gravin also acts as an autoantigen in myasthenia gravis patients . Monoclonal Anti-Gravin antibody is specific for human, rat and mouse gravin (approx. 300 kDa).
Application: Monoclonal Anti-Gravin antibody is suitable for use in immunoblotting (using mpkCCD cells ). The product may also be used for immunocytochemistry and immunoprecipitation.
Immunogen: fractionated membrane cortex proteins from human neuron cell lines NT2-N and SK-N-BE(2).
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
RIDADR: NONH for all modes of transport
WGK Germany: 3