MDL No.: MFCD01865484
Storage: -20C
UNSPSC Code: 12352203
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Application: Monoclonal Anti-Granzyme B antibody is suitable for western blot and immunocytochemistry at a dilution of 1:20 using pretreated tissues.
Biochem/physiol Actions: Granzyme B, neutral serine protease, is expressed in cytoplasmic granules of activated cytotoxic T lymphocytes and natural killer cells. It contains a leader sequence (cleaved by a signal peptidase) and two amino acid prodomains (cleaved by the lysosomal cysteine protease DPPI). It plays a major role in the caspase dependent apoptotic pathway by activating most of the caspases in vitro and in vivo. It cleaves the aspartic acid residues, to facilitate cell death by various pathways. It has been shown that granzyme B has capacity to facilitate cytochrome C release from the mitochondria in a caspase independent way.
Immunogen: recombinant human granzyme B.
Physical form: Supplied in serum-free culture medium containing 1% bovine serum albumin and 0.1% sodium azide.
Specificity: Does not cross-react with granzyme A.