Synonyms: ML 348; ML-348; N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-furoyl)-1-piperazinyl]acetamide
Molecular Formula: C18H17ClF3N3O3
Molecular Weight: 415.79
Linear Structural Formula: C18H17ClF3N3O3
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: ML348 is a substrate-competitive, reversible and APT1-selective acyl-protein thioesterase (APT) inhibitor (IC50/Ki = 840 nM/300 nM against APT1; IC50 & Ki >10 muM against APT2). ML348 effectively inhibits cellular APT1 activity in cultures (by >95% in HEK293T & mouse T cells; 5 muM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT2.