Cytokine receptors constitute an integral part of cytokine biology. Like cytokines, cytokine receptors are involved in normal physiological and pathological processes of almost all disease states. Soluble cytokine receptors naturally arise from genes encoding membrane- bound receptors or are direct derivatives of the receptors themselves. The discovery that soluble cytokine receptors are involved in regulating excessive inflammatory responses and modulating immune events has stimulated significant research interest in their potential role as immunotherapeutic agents. Many of these soluble cytokine receptors can inhibit the binding and biological activity of their cytokine ligands, making them very specific cytokine antagonists. MILLIPLEX(R) Human Soluble Cytokine Receptor Panel is to be used for the simultaneous quantification of 14 soluble cytokine receptors in human serum, plasma and cell / tissue culture supernatant samples. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate. The Luminex(R) xMAP(R) platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume. Panel Type: Cytokines/Chemokines
Application:
•Analytes: sCD30, sEGFR, sGP130, sIL-1RI, sIL-1RII, sIL-2Ralpha, sIL-4R, sIL-6R, sRAGE, sTNFRI, sTNFRII, sVEGFR1, sVEGFR2, sVEGFR3
•Recommended Sample type: Serum, plasma or tissue/cell lysate and culture supernatant
•Recommended Sample dilution: 1:5 dilution for plasma or serum or neat cell culture supernatant
•Assay Run Time: Overnight
•Research Category: Inflammation & Immunology
Legal Information: xMAP is a registered trademark of Luminex Corp
Other Notes: Sensitivity: Please see kit protocol for individual assay sensitivities.