Synonyms: 2-(4-Heptylphenethyl)-6-hydroxybenzoic acid; 2-[2-(4-Heptylphenyl)ethyl]-6-hydroxybenzoic acid; MG 149
Molecular Formula: C22H28O3
Molecular Weight: 340.46
Linear Structural Formula: C22H28O3
MDL Number: MFCD22123243
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: MG149 is cell-permeable anacardic acid analog that displays higher selectivity towards MYST type HATs (IC50 = 47 and 74 muM against MOF and Tip60; Ki for KAT8 = 39 muM) over p300 and PCAF (IC50 > 200 and >> 200 uM). Tip60 inhibition is shown to be Ac-CoA competitive and histone substrate non-competitive and KAT8 inhibition is Ac-CoA uncompetitive. MG149 treatment lowers histone acetylation levels and cellular proliferation rate, induces apoptosis and dose-dependently alters pro-inflammatory cytokines/chemokines expression. Enhances JQ1-induced HIV latency reversal, suppresses NOX transcription and ameliorates ROS levels.