The C2BBe1 cells, a subclone of Caco-2 cells, correspond to ATCC CRL-2102. The MDR1 and BCRP knockout C2BBe1 cells are adenocarcinoma, epithelial cells from a human caucasian male (aged 72 years) with functional knockout of the ABCB1 and ABCG2 (MDR1/BCRP) efflux transporters.
Synonyms: C2BBe1 Cells MDR1/BCRP (-/-/-/-,-/-/-/-)
Storage: -196C
Application: The following posters and articles demonstrate how Caco-2 cells can be used for cell based assays:Transporter Function in Caco-2 Cells with Targeted P-Glycoprotein, MRP2 and BCRP Gene Knockout Using Zinc Finger NucleasesComparison of Function and Relative Transporter Protein Concentrations in Caco-2 Cells with Single and Double Knockouts of the ABCB1, ABCG2, and ABCC2 GenesCaco-2 Transporter Knockout Cell Based Assays
Legal Information: ADME/Tox Cell Lines License