Synonyms: 1,1-Dimethylbiguanide hydrochloride; Metformin
Formula: NH2C(=NH)NHC(=NH)N(CH3)2 · HCl
Formula Weight: 165.62
CAS No.: 1115-70-4
Biochem/physiol Actions: Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.
Grade: certified reference material
MP: 223-226°C(lit.)
Packaging: pkg of 500 mg
Pharmacopeia Traceability: traceable to USP 1396309