Synonyms: (alphaS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-
Molecular Formula: C37H48N4O5
Molecular Weight: 628.8
Linear Structural Formula: C37H48N4O5
Purity: >=98% (HPLC)
Storage: -20C
Application: Lopinavir has been used as a ZMPSTE24 and human immunodeficiency virus protease inhibitor.
Biochem Physiol Actions: Lopinavir is an antiviral HIV Protease Inhibitor. Lopinavir has insufficient bioavailability alone, so it is used in therapy in combination with Ritonavir, a HIV protease inhibitor, which inhibits cytochrome P450-3A4 (CYP3A4), a liver enzyme that normally metabolizes protease inhibitors. Lopinavir also has an ability to inhibit ZMPSTE24 (zinc metallopeptidase STE24).