Synonyms: (4S)-3-[(2S,3S)-3-Hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-2-oxazolidinone
Molecular Formula: C17H29NO4
Molecular Weight: 311.42
Linear Structural Formula: C17H29NO4
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: LMT-28 is an IL-6 antagonist that targets the IL-6 Receptor beta subunit, Glycoprotein 130 (gp130). Its binding to gp130) results in inhibition of IL-6 activation, and downregulation of levels of p-STAT3. LMT-28 was shown to stimulate phosphorylation of STAT3 and JAK2 protein. IL-6 dysregulation is involved in inflammation and cancers. LMT-28 had inhbitory activity against IL-6-dependent TF-1 cell proliferation and also had therapeutic effect against pancreatitis.