Synonyms: 2-Chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]-phenol; L 779450
Molecular Formula: C20H14ClN3O
Molecular Weight: 347.8
Linear Structural Formula: C20H14ClN3O
MDL Number: MFCD12828750
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: L-779450 is a potent inhibitor in Raf-induced proliferation of Raf-1 and A-Raf-1 kinases. Raf inhibition is a target for anti-cancer therapy. Raf exists in three isoforms: Raf-1, A-Raf, and B-Raf, which are expressed at different levels in different cell types, tissues, and cancer states. L-779450 compound's pharmacology found it to inhibit proliferation in Raf-1 and A-Raf, but not B-Raf responsive cells. L-779450 has been used as a reference Raf inhibitor to discover other compounds.