Synonyms: N-benzyl-2-chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide
Molecular Formula: C17H16ClNO3
Molecular Weight: 317.77
Linear Structural Formula: C17H16ClNO3
Purity: >=95% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: JNS 1-40 is a potent and selective cysteine-reactive covalent ligand of regulatory subunit PPP2R1A of the tumor-suppressor protein phosphatase 2A (PP2A) that activate PP2A in vitro and in vivo. JNS 1-40 targets C377 of PPP2R1A and inhibits breast cancer proliferation, and in vivo tumor growth.