Synonyms: 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl]-3-pyridinecarboxamide
Molecular Formula: C28H32N4O2S
Molecular Weight: 488.64
Linear Structural Formula: C28H32N4O2S
MDL Number: MFCD28334214
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: JNJ-47965567 is a potent P2X7 antagonist with high affinity for the rat receptor (pKi = 8.7). It is centrally available after systemic injection with a superior brain:plasma distribution compared to other available P2X7 antagonists. JNJ-47965567 was shown to suppress epileptic seizures in a mouse model of epilepsy. It appears to have a disease modifying effect since spontaneous seizure rates did not increase once treatment with JNJ-477965567 was stopped.