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MilliporeSigma

J113863, cis isomer >97% (HPLC)

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Synonyms: 1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide; Piperidinium, 1-(1-cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethyl-, iodide (1:1), cis-

Molecular Formula: C30H37Cl2IN2O2

Molecular Weight: 655.44

Linear Structural Formula: C30H37Cl2IN2O2

MDL Number: MFCD09971133

Purity: >97% (HPLC)

Storage: 2-8C

Biochem Physiol Actions: J113863 is a high affinity antagonist for CCR1 and CCR3 receptors. Also both J113863 and its enantiomer c exhibit low binding affinity toward CCR2 and CCR5 where they activate three Gi and two G0 protein isoforms. J113863 does not activate G12 protein isoform. J113863 binding to CCR2 and CCR5 induce the recruitment of b-arrestin 2 whereas UCB35625 did not. J113863 and UCB35625 are biased ligands for the chemokine receptors CCR2 and CCR5.

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Product Detail
Thomas No.
CHM03J409
Mfr. No.
SML1977-5MG
Description
SML1977-5MG, J113863, cis isomer >97% (HPLC)
CAS Number
202796-41-6
list price/quantitytotal
$0.00
Thomas No.
CHM03J410
Mfr. No.
SML1977-25MG
Description
SML1977-25MG, J113863, cis isomer >97% (HPLC)
CAS Number
202796-41-6
list price/quantitytotal
$0.00
$0.00 (0 Items)
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