Synonym(s): IL-3; mIL-3; Interleukin-3 from mouse
Purity: ≥98% (SDS-PAGE and HPLC)
Physical form: Lyophilized with 0.5 mg of bovine serum albumin. Sterile filtered through a 0.2 μm filter.
Analysis Note: The biological activity is measured by the dose-dependent stimulation of the proliferation of mouse M-NFS-60 cells.
Storage: −20°C
Biochem/physiol Actions: Interleukin-3 is a multifunctional protein, originally called colony forming unit-stimulating activity (CFU-SA), and is produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 has been shown to induce colony formation of macrophages, neutrophils, mast cells, and megakaryocytes from agar-suspended bone marrow cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and to induce IgG secretion from activated B cells. Other synonyms for IL-3 include pan-specific hemopoietin, multicolony stimulating factor, mast cell growth factor, burst promoting activity, histamine-producing cell stimulating factor, P cell stimulating factor, and WEHI-3 factor.
Empirical Formula (Hill Notation): C3H9NO