A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.
Synonyms: InSolution Tamoxifen, 4-Hydroxy-, ( Z)- - CAS 68047-06-3 - Calbiochem; ( Z)-4-(1-(4-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl)phenol, ( Z)-4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol, (Z)-4-Hydroxytamoxifen, (Z)-4-OH-TAM, trans-4-Hydroxytamoxifen
Molecular Formula: C26H29NO2
Molecular Weight: 387.51
Linear Structural Formula: C26H29NO2
MDL Number: MFCD00278780
Purity: >=99% (HPLC)
Biochem Physiol Actions: Primary TargetEstrogen receptor
Legal Information: CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes: Gundimeda, U., et al. 1996. J. Biol. Chem.271, 13504.Ye, Q. and Bodell, W.J. 1996. Carcinogenesis17, 1747.Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol.21, 985.Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health4, 364.