Interleukin-1a (IL1a) is also known as IL-1A, IL1, IL1-a, IL1F1, and is a cytokine of the interleukin-1 family. IL-1a is constitutively produced by epithelial cells. It is found in substantial amounts in normal human epidermis and is distributed in a 1:1 ratio between living epidermal cells and stratum corneum. The gene encoding this protein is localized on human chromosome 2.
Synonyms: IL-1alpha; IL-1A; IL1; IL1 ALPHA; IL1-ALPHA; IL1A; IL1F1; Interleukin; Interleukin-1 alpha
Purity: >=97% (SDS-PAGE)
Storage: -20C
Biochem Physiol Actions: Interleukin-1a (IL1a) possesses a wide spectrum of metabolic, physiological, hematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. The constitutive production of large amounts of IL-1a precursor by healthy epidermal keratinocytes interfere with the important role of IL-1a in immune responses, assuming skin as a barrier, which prevents the entry of pathogenic microorganisms into the body. In vitro, IL-1a possesses biological effect on cells in the picomolar to femtomolar range. In vivo, shortly after an onset of an infection into organism, IL-1a activates a set of immune system response processes.