Synonyms: Gentamicin sulfate salt
CAS No.: 1405-41-0
Storage Temperature: 2-8°C
Application: Used as a selection agent (gentamicin-resistance gene) in molecular biology applications.
Biochem/physiol Actions: Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site.1,2 The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.3
Antimicrobial spectrum: Gram-negative bacteria, Staphylococcus aureus and other Gram-positive bacteria
Protocols & Applications: Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information