Synonyms: Gentamicin sulfate salt; Garamycin; Gentiomycin C
CAS No.: 1405-41-0
Storage Temperature: 2-8°C
Application: Used as a selection agent (gentamicin-resistance gene) in molecular biology applications.
Biochem/physiol Actions: Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site.1,2 The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.3
Antimicrobial spectrum: Gram-negative bacteria, Staphylococcus aureus and other Gram-positive bacteria
Form: powder
Solubility: H2O: soluble50 mg/mL (As a stock solution. Stock solutions should be stored at −20-á°C.)
Storage Temp.: 2-8°C
Suitability: meets USP testing specifications