Synonyms: 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]-acetic acid; GW1516
Molecular Formula: C21H18F3NO3S2
Molecular Weight: 453.5
Linear Structural Formula: C21H18F3NO3S2
MDL Number: MFCD09033000
Purity: >=98% (HPLC)
Storage: -20C
Application: GW501516 has been used to study its effect on mutation-driven colorectal tumorigenesis and tumor invasion using mouse model.
Biochem Physiol Actions: PPARd activation by GW501516, retards weight gain through fatty acid catabolism in adipose tissue and skeletal muscles. GW501516 causes an increase in the levels high-density lipoprotein cholesterol and apolipoprotein A (apoA) and reduction in the low density-lipoprotein cholesterol, apoB, and triglyceride.