Synonyms: 5-Amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide; GRL 0617; GRL0617
Molecular Formula: C20H20N2O
Molecular Weight: 304.39
Linear Structural Formula: C20H20N2O
MDL Number: MFCD12547683
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: GRL-0617 is a cell penetrant non-cytotoxic and potent inhibitor of the SARS-CoV -2 papain-like protease (SCoV2-PLpro) and SCoV-PLpro. GRL-0617 reversibly binds to SCoV2-PLpro and disrupts its interaction with Interferon-stimulated gene 15 (ISG15). GRL-0617 poorly affects (> 100 muM) the activities of MERS PLpro, a series of cysteine proteases, including the human deubiquitinating enzymes HAUSP, USP18, UCH-L1, UCH-L3, and a papain-like protease (PLP2) from the human coronavirus NL63. GRL-0617 suppress SARS-CoV-2 infection and promote anti-viral immunity.