Synonyms: SRC2; c-fgr; p55c-fgr
Purity: >=70% (SDS-PAGE)
Activity: activity: 242-328 nmol/min·mg
Storage: -70C
UNSPSC Code: 12352200
General description: Src family of tyrosine kinases is grouped into two classes- those with wide range of expression, and those with narrow range of tissue expression. Fgr belongs to the latter group. This protein has six functional domains namely, Src homology domain 4 (SH4), a unique domain, SH3 domain, SH2 domain, the catalytic SH1 domain, and a regulatory region in C-terminal. It is expressed in natural killer cells, monocytes and granulocytes.
Biochem/physiol Actions: FGR interacts with Fc?RII and thus, regulates Fc?RII-mediated signaling cascade.This protein is expressed in B-cells of patients with Epstein-Barr virus-associated lymphoproliferative disease and chronic lymphocytic leukemia. It is also expressed in normal mantle zone B-cells and is controlled developmentally during the differentiation of myelomonocytes.
Physical form: Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
RIDADR: NONH for all modes of transport
WGK Germany: 1