Synonyms: (oh)4Cyd; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyamino)pyrimidin-2(1H)-one; 4-N-HO-Cyd; BHC; EIDD 1931; EIDD 2801 metabolite; EIDD-2801 metabolite; EIDD1931; EIDD2801 metabolite; N4-Hydroxycytidine; N4-OHcyd; N4OHcyd; NHC; beta-D-N4-Hydroxycytidine
Molecular Formula: C9H13N3O6
Molecular Weight: 259.22
Linear Structural Formula: C9H13N3O6
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: Originally recognized as a powerful mutagen that preferentially induces AT-to-GC transition in microorganisms, EIDD-1931 (NHC, N4-hydroxycytidine) is an orally available ribonucleoside analog with known anti-viral activity against SARS-CoV, SARS-CoV-2, respiratory syncytial virus (RSV), influenza A & B viruses (IAV & IBV), HCV, pestivirus, bovine viral diarrhoea virus (BVDV), Ebola virus (EBOV), Chikungunya virus (CHIKV), venezuelan equine encephalitis virus (VEEV). NHC effectively reduces RSV and IAVs replication in mice, and exhibts efficacy in a guinea pig IAV transmission model in vivo (100 & 400 mg/kg b.i.d. p.o.). Metabolic studies reveal species-dependent plasma stability.