Synonym: 6-Maleimidocaproic acid N-succinimidyl ester, N-(ε-Maleimidocaproyloxy)succinimide, N-Succinimidyl 6-maleimidocaproate, EMCS
CAS Number: 55750-63-5
Empirical Formula (Hill Notation): C14H16N2O6
Molecular Weight: 308.29
Beilstein Registry Number: 1499815
MDL Number: MFCD00043043
Application
A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5) The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Contains 9 atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.
Packaging
10, 25, 100 mg in glass bottle
Assay: ≥98%
Form: powder
MP: 70-73 °C(lit.)
Solubility: chloroform: soluble100 mg/mL; DMF: soluble (lit.)(lit.)
Storage Temp.: −20°C