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MilliporeSigma

d0-DMDSSO crosslinker >=95%

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Synonyms: Bis(2,5-dioxopyrrolidin-1-yl) 3,3'-sulfinylbis(2-methylpropanoate); Mass spectrometry-cleavable crosslinker for studying protein-protein interactions

Molecular Formula: C16H20N2O9S

Molecular Weight: 416.4

Linear Structural Formula: C16H20N2O9S

Purity: >=95%

Storage: 2-8C

Application: d0-DMDSSO (dimethyl-disuccinimidyl sulfoxide) crosslinker is a homobifunctional, lysine residue-targeting, sulfoxide-containing crosslinker for analysis of protein-protein interactions (PPIs) through crosslinking mass spectrometry (XL-MS). d0-DMDSSO possesses two N-hydroxysuccinimide (NHS) ester groups for targeting amines and two symmetrical C-S cleavable bonds adjacent to the central sulfoxide. The post-cleavage spacer yields tagged peptides for unambiguous identification by collision-induced dissociation in tandem MS. d0-DMDSSO crosslinker will also be a useful proteomics tool and aid in the quest for targeting "undruggable" protein targets.

Legal Information: Subject to US Patent Application #15/275,001 of the Regents of the University of California

Other Notes: Technology Spotlight: Cross-Linkers for Elucidation of Protein-Protein InteractionsDeveloping New Isotope-Coded Mass Spectrometry-Cleavable Cross-Linkers for Elucidating Protein Structures

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Product Detail
Thomas No.
CHM03K402
Mfr. No.
909661-100MG
CAS #
1554583-88-8
Description
909661-100MG, d0-DMDSSO crosslinker >=95%
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