Synonyms: Bis(2,5-dioxopyrrolidin-1-yl) 3,3'-sulfinylbis(2-methylpropanoate); Mass spectrometry-cleavable crosslinker for studying protein-protein interactions
Molecular Formula: C16H20N2O9S
Molecular Weight: 416.4
Linear Structural Formula: C16H20N2O9S
Purity: >=95%
Storage: 2-8C
Application: d0-DMDSSO (dimethyl-disuccinimidyl sulfoxide) crosslinker is a homobifunctional, lysine residue-targeting, sulfoxide-containing crosslinker for analysis of protein-protein interactions (PPIs) through crosslinking mass spectrometry (XL-MS). d0-DMDSSO possesses two N-hydroxysuccinimide (NHS) ester groups for targeting amines and two symmetrical C-S cleavable bonds adjacent to the central sulfoxide. The post-cleavage spacer yields tagged peptides for unambiguous identification by collision-induced dissociation in tandem MS. d0-DMDSSO crosslinker will also be a useful proteomics tool and aid in the quest for targeting "undruggable" protein targets.
Legal Information: Subject to US Patent Application #15/275,001 of the Regents of the University of California
Other Notes: Technology Spotlight: Cross-Linkers for Elucidation of Protein-Protein InteractionsDeveloping New Isotope-Coded Mass Spectrometry-Cleavable Cross-Linkers for Elucidating Protein Structures