• PRODUCT AVAILABILITY: Did you know you can view a product's availability right on the product page? Simply enter the quantity you want to purchase and the current availability will appear below the item.

  • Product is restricted and can only be purchased by customers with a web profile linked to a Thomas Business Account - Click here to login or create your web profile. If you do not have a Thomas Business Account, please Contact Us and someone will respond with details on how to apply for a business account with us.

MilliporeSigma

DHSO crosslinker

Not yet rated

Synonyms: 3,3'-Sulfinyldi(propanehydrazide); Dihydrazide sulfoxide; Mass spectrometry-cleavable crosslinker for studying protein-protein interations

Molecular Formula: C6H14N4O3S

Molecular Weight: 222.27

Linear Structural Formula: C6H14N4O3S

Storage: 2-8C

Application: DHSO Crosslinker is a homobifunctional, acidic residue-targeting, sulfoxide-containing crosslinker for analysis of protein-protein interactions (PPIs) through crosslinking mass spectrometry (XL-MS). DHSO possesses two hydrazide-reactive groups for targeting aspartic acid (Asp) and glutamic acid (Glu) and two symmetrical C-S cleavable bonds adjacent to the central sulfoxide. While former amine-reactive reagents react with lysine (Lys) residues in proximity to the PPI, targeting acidic residues provides further opportunity to characterize protein interaction surfaces at which Asp and Glu are often prevalent. Additionally, the 12.4 Å spacer yields tagged peptides post-cleavage for unambiguous identification by collision-induced dissociation in tandem MS. DHSO Crosslinker provides complementary data to Lys-targeting reagents and will find wide utility in the elucidation of PPIs, study of proteins that function as complexes, quantification of structural dynamics, and quest for targeting "undruggable" protein targets.

Legal Information: Subject to US Patent Application #15/613,065 of the Regents of the University of California

Other Notes: Technology Spotlight: Cross-Linkers for Elucidation of Protein-Protein InteractionsDeveloping an Acidic Residue Reactive and Sulfoxide-Containing MS-Cleavable Homobifunctional Cross-Linker for Probing Protein-Protein InteractionsDevelopment of a Novel Sulfoxide-Containing MS-Cleavable Homobifunctional Cysteine-Reactive Cross-Linker for Studying Protein-Protein InteractionsStructural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling

Please Enter Your Order Info

Filter by:

  • Clear Filters
Product Detail
Thomas No.
CHM02N391
Mfr. No.
909599-100MG
CAS #
1971857-82-5
Description
909599-100MG, DHSO crosslinker
list price/quantitytotal
$0.00
$0.00 (0 Items)
Product is restricted and can only be purchased by customers with a web profile linked to a Thomas Business Account - Click here to login or create your web profile. If you do not have a Thomas Business Account, please Contact Us and someone will respond with details on how to apply for a business account with us.

Write A Review