Synonyms: 1-(2-(Diethylamino)ethyl)-3-(2-(4-ethylpiperazin-1-yl)-4-methylquinolin-6-yl)thiourea; N-[2-(Diethylamino)ethyl]-N'-[2-(4-ethyl-1-piperazinyl)-4-methyl-6-quinolinyl]-thiourea
Molecular Formula: C23H36N6S
Molecular Weight: 428.64
Linear Structural Formula: C23H36N6S
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: D-I03 is a selective RAD52 inhibitor (IC50 = 5 and 8 muM, respectively, by SSA and DNA pairing (D-loop formation) assay;<5 % rad51 inhibition at 80 mum) that blocks single-strand dna (ssdna) annealing (ssa)-, but not homology dependent recombination (hdr)-, mediated double-strand break (dsb) repair (5-30 mum using respective u2os reporter cells) and reduces nuclear rad52, but not rad51, foci formation (2.5 mum) upon dna damage by cisplatin. d-i03 selectively suppresses brca1-deficient over brca1-proficient cancer cells and exerts synergistic activity with parp1 inhibitors against brca1-deficient cancer both in cultures (1 & 2.5 mum) and in mice (50 mg g ay i.p.) in vivo.<>