Synonyms: 3',5'-Cyclic diguanylic acid sodium salt; Bis(3',5')-cyclic diguanylic acid sodium salt; Cyclic Diguanosine-5'-monophosphate sodium salt; c-di-GMP sodium salt; c-diGMP sodium salt; cGpGp sodium salt
Molecular Formula: C20H24N10O14P2 · xNa+
Linear Structural Formula: C20H24N10O14P2 · xNa+
Purity: >=98% (HPLC)
Storage: -20C
Application: Cyclic-di-GMP sodium salt has been used as a quorum sensing molecule.
Biochem Physiol Actions: Cyclic-di-GMP is a naturally occurring small molecule that acts as a bacterial second messenger to regulate important signaling mechanisms in prokaryotes that control bacterial survival, adhesion, colonization, biofilm formation, and virulence factors production. During infections Cyclic-di-GMP is bound by host STING (stimulator of interferon genes) leading to expression of interferon genes, activating innate immune responses. c-di-GMP has been found in eukarotic systems acting not only in immune response, but as an inhibitor of the pacemaker I(f) current in the heart.