a-Ketoglutaric acid, an a-ketoacid, is identified as a potential, renal cell carcinoma (RCC) biomarker via urinary metabolomic profiling. It plays an important role in living beings as an angiogenesis suppressor.
Synonyms: 2-Oxoglutaric acid; 2-Oxopentanedioic acid
Molecular Formula: C5H6O5
Molecular Weight: 146.1
Linear Structural Formula: HOOCCH2CH2COCOOH
MDL Number: MFCD00004165
Purity: 99.0-101.0% (T)
Storage: 2-8C
Application: a-Ketoglutaric acid may be used as an analytical reference standard for the quantification of the analyte in the following:
•Human plasma samples using gas-chromatography coupled to mass spectrometry.
•Beer samples using high-performance liquid chromatography with UV detection, and further confirmed by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).
•Fruits and vegetables using HPLC-MS/MS.