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MilliporeSigma

Azide-A-DSBSO crosslinker >=95%

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Synonyms: Azide-tagged acid-cleavable disuccinimidyl bissulfoxide; Bis(2,5-dioxopyrrolidin-1-yl) 3,3'-((2-(3-azidopropyl)-2-methyl-1,3-dioxane-5,5-diyl)bis(methylenesulfinyl))dipropionate; Mass spectrometry-cleavable crosslinker for studying protein-protein interations

Molecular Formula: C24H33N5O12S2

Molecular Weight: 647.68

Linear Structural Formula: C24H33N5O12S2

Purity: >=95%

Storage: 2-8C

Application: Azide-A-DSBSO (azide-tagged, acid-cleavable disuccinimidyl bissulfoxide) Crosslinker is a homobifunctional, membrane-permeable, enrichable disulfoxide-containing crosslinker for analysis of protein-protein interactions (PPIs) through crosslinking mass spectrometry (XL-MS). Azide-A-DSBSO possesses two N-hydroxysuccinimide (NHS) ester groups for targeting amines, a >=14 Å spacer length, two symmetrical acid-cleavable C-S bonds, and a central bioorthogonal azide tag. After reacting with lysine (Lys) residues, the azide tag permits selective enrichment of crosslinked proteins or peptides with a biotin-conjugated alkyne probe to enhance their detection. Additionally, the post-cleavage spacer yields tagged peptides for unambiguous identification by collision-induced dissociation in tandem MS. Azide-A-DSBSO Crosslinker has mapped in vivo PPIs for target protein complexes and whole proteomes from living cells. It will also be a useful proteomics tool in the quest for targeting "undruggable" protein targets.

Legal Information: Subject to US Patent Application #15/275,001 of the Regents of the University of California

Other Notes: Technology Spotlight: Cross-Linkers for Elucidation of Protein-Protein InteractionsA New in Vivo Cross-linking Mass Spectrometry Platform to Define Protein-Protein Interactions in Living CellsSynthesis of two new enrichable and MS-cleavable cross-linkers to define protein-protein interactions by mass spectrometry

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Product Detail
Thomas No.
CHM02F664
Mfr. No.
909629-100MG
CAS #
1704097-02-8
Description
909629-100MG, Azide-A-DSBSO crosslinker >=95%
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