Aprotinin from bovine lung saline solution, 3-7 TIU/mg protein

Synonym: Trasylol, Trypsin inhibitor (basic)

CAS Number: 9087-70-1

Empirical Formula (Hill Notation): C₂₈₄H₄₃₂N₈₄O₇₉S₇

Molecular Weight: 6511.44

MDL Number: MFCD00130541

Analysis Note
Another commonly used unit of activity is the KIU (Kallikrein Inhibitor Unit). 1 TIU ∼ 1,300 KIU. Protein determined by biuret.

Quality
Contains 5-10 TIU per mL solution.

Unit Definition
One trypsin inhibitor unit (TIU) will decrease the activity of 2 trypsin units by 50% where one trypsin unit will hydrolyze 1.0 μmole of N-α-benzoyl-DL-arginine p-nitroanilide (BAPNA) per min at pH 7.8 at 25 °C.

Physical Form
Solution in 0.9% NaCl and 0.9% benzyl alcohol.

General Description
Aprotinin is a protein consisting of 58 amino acids, arranged in a single polypeptide chain that is crosslinked by three disulfide bridges.