STK10 (serine/threonine kinase 10), also called lymphocyte-oriented kinase (LOK) is a member of the STE20 family. Its N-terminal contains the catalytic domain, and contains the characteristic eleven sub-domains of serine/threonine kinases. Its C-terminal is made of a-helices, which are thought to form a coiled-coil domain. It contains predicted SH3-binding motifs, PXXP, which is proline-rich, in between the coiled-coil domain and the active site. This gene is localized to human chromosome 5q35.1, and its expression is almost exclusive to lymphoid cells. However, it is also expressed in brain, kidney, lung, liver, small intestine and colon.
Synonyms: Anti-LOK; Anti-PRO2729; Anti-serine/threonine kinase 10
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: STK10 (serine/threonine kinase 10) has multiple cellular functions such as, the control of cell growth, cytoskeleton dynamics and cell motility and apoptosis. It is a tumor suppressor gene, and mutations or variants in this gene might lead to tumorigenesis. In T-cells, it acts as an antagonist of MAP kinase/ERK kinase-1 (MEKK1), when acting upon CD28RE (response element)/AP1 element. It suppresses the production of IL-2 in Jurkat cells. Studies in Korean subjects show that variants in this gene are associated with susceptibility to aspirin-intolerant asthma.
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