Sprouty related EVH1 domain containing 1 (SPRED1) is encoded by the gene mapped to human chromosome 15q14. The encoded protein belongs to the SPROUTY/SPRED family of proteins. SPRED1 is predominantly expressed in hematopoietic cells.
Synonyms: Anti-FLJ33903; Anti-PPP1R147
Storage: -20C
Application: Anti-SPRED1 antibody produced in rabbit has been used in immunohistochemistry.
Biochem Physiol Actions: Sprouty related EVH1 domain containing 1 (SPRED1) acts as a negative regulator of Ras by hindering the phosphorylation of Raf. The encoded protein negatively regulates mast cell activation and high affinity immunoglobulin E receptor (FceRI)-mediated cytokine production, which is controlled by miR126. SPRED1 also plays a vital role in neural and behavioral plasticity. Mutation in the gene leads to legius syndrome and neurofibromatosis type 1 (NF1)-like syndrome (NFLS).
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