SRgamma (sex determining region gamma) (SOX) are HMG box containing transcription factors that bind to the minor groove of DNA. Sox proteins family members regulate a variety of aspects of development. SRgamma (sex determining region gamma)-box 4 (SOX4, EVI16, SRgamma) is required for differentiation and proliferation in many tissues, including various cancers. Sox4 acts in part by stabilizing beta-catenin. Sox4 is required for lymphocyte development. It is an early factor in B-cell differentiation.
Synonyms: Anti-EVI16; Anti-SRY (sex determining region Y)-box 4
Storage: -20C
Application: Anti-SOX4 polyclonal antibody is used to tag SRgamma (sex determining region gamma)-box 4 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of SRgamma (sex determining region gamma)-box 4 in cell differentiation and proliferation, such as B-cell differentitation.
Biochem Physiol Actions: SRY box 4 (SOX4) is required for differentiation and proliferation in many tissues, including various cancers. It stabilizes ß-catenin. Sox4 is essential for lymphocyte development. It acts as an early factor in B-cell differentiation. SOX4 is involved in the regulation of embryonic development and the determination of cell fate. It acts as a transcriptional regulator after forming syndecan binding protein (syntenin), a protein complex. SOX4 modulates the apoptosis pathway, which leads to cell death and tumorigenesis. It regulates downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development.